Mechanism of T2DM correlate with patient’s metabolic status and immune respon. Previous studies shown that physical activity reduce insulin resistance and enhance immune system. The aims of this study were to get the profile of physical activity, metabolic state, and mononuclear cell response to the expression of the TLR2 and TLR4 genes in T2DM patients. It was a descriptive-analytic study with a cross-sectional study design. Thirty-two eligible patients with inclusion criteria participated as subjects. All subjects answered questions by IPAQ, and checked metabolic state with body composition analysis. The TLR2 and TLR4 gene expression was determined with quantitative Real- Time PCR. This study result found that most T2DM patients were in a highly active category in which most of their activity was walking (light intensity). The average abdominal circumferences were 91.81 ± 15.4 cm, body fat percentage was 29.5 ± 8.8%, and fasting blood sugar was 187.07 ± 67.03 mg/dl. Mononuclear cells number were normal. The expression of the TLR2 gene was lower by 0.71 fold and TLR4 gene expression was lower by 0.9 fold compared with non-DM (p<0.05). By Chi-square test, there was a positive correlation between the abdominal circumference and TLR4 gene expression (p=0.011). Type-2 diabetes mellitus patients in primary health care keep walking as their physical activity to maintain glucose level. Patients need to do moderate to vigorous exercise regularly to reduce much more Toll-like receptor gene expression, insulin resistance and blood glucose level decline to normal.

Yetty Machrina is a Physiologist and Family Medicine Doctor has completed his PhD at the age of 40 years from Universitas Sumatera Utara, Indonesia. She is the head of Physiology Department, Faculty of Medicine, Universitas Sumatera Utara. Her expertise field is human physiology and exercise physiology. She has several publication in both National and International journal with interest research are exercise physiology, non communicable diseases, Sport medicine. She has been serving as reviewer and editorial board member of several journal.