Pablo MuñozUniversidad de Valparaíso, Chile
Title: Brain-permeant antioxidants improved recognition memory, synaptic plasticity and neuroinflammatory response
Given the increase in life expectancy of the current population, a higher prevalence of neuro- degenerative pathologies and cognitive impairment has been observed in the elderly. In this regard, compelling evidence relates brain aging with oxidative damage which is detrimental to cellular and molecular processes related to neuronal plasticity and memory. In this work, we study the effect of brain-permeant antioxidants on recognition memory, synaptic plasticity, neuroinflammation and antioxidant responses. To that end, young (2-5 months) and aged (18 months) Sprague Dawley rats were fed with normal diet supplemented with a powerful carotenoid of marine origin (astaxanthin: ASX; 4 mg/day) or vehicle (n = 6 per group) for 20 days. We found that aged rats treated with ASX significantly improved behavioral performance on a spontaneous object recognition task. In hippocampal neurons, age induces an inflammatory response mediated by nuclear translocation of nuclear factor kappa beta. This effect that was significantly diminished in aged rats supplemented with ASX. Moreover, ASX significantly increases the antioxidant response of NAD(P)H dehydrogenase [quinone] 1 gene, in aged rats. Consistently, aged rats fed with a recently patented chitosan-based antioxidant nanofiber (NF) that permeates the BBB, enhanced long-term potentiation which is a type of hippocampal plasticity. NF also decreased age- induced DNA oxidation. Our data suggest that brain-permeant antioxidants such as ASX and/or NF, could be promising therapeutic agent against the age-associated diseases.
Pablo Muñoz has completed his PHD at the age of 34 years from Universidad de Chile, Chile. He is the director of Center for Translational Neurology, Universidad de Valparaíso, Chile. He has over 28 publications that have been cited over 975 times, and his publication h-index is 17. He has developed two patents. He has been serving as an editorial board member of several reputed journals.