Virtual Conference

Ana Ruth Cadena Suárez

National Institute of Respiratory Diseases, México

Title: MiRNAs involved in the signaling pathways associated to the pathogenesis of idiopathic pulmonary fibrosis

Abstract

Idiopathic Pulmonary Fibrosis (IPF) is a progressive and degrading interstitial lung disease whose pathophysiology remains unclear, with poor prognosis and few therapeutic options. Nowadays several studies have associated microRNAs (miRNAs) to the biogenesis and development of IPF because miRNAs participate in the processes of apoptosis, proliferation, differentiation and interaction between cells thanks to their role as activators or inhibitors of different receptors in the signaling pathways of TGF-?, Wnt/?-catenin and PI3K-Akt-FOXO3a-mTOR, which are the main and most studied pathways involved in lung fibrosis both in human and murine fibrosis models. MiRNAs can cause a remodeling effect of lung parenchyma through fibroblasts trans differentiation into myofibroblasts with the consequent synthesis of extracellular matrix proteins that contribute with the fibrotic process. The knowledge on the altered miRNAs expression and even more their role in the different signaling pathways in IPF will shed light on new therapeutic targets for this lung disease because if it is possible to modify or block the action of a specific miRNA it could generate a change in the mechanism of the disease. Although it is not yet known whether this therapy will have adverse effects, it is believed that therapy based on miRNAs could be the basis of an effective treatment for pulmonary fibrosis. However, it is suggested to expand the studies about miRNAs involved in IPF so that in the future, being able to help patients suffering from this chronic and devasting disease by proposing a new therapeutic agent more effective than those existing today.

Biography

Ana Ruth Cadena Suárez has completed the medicine career at the National Autonomous University of Mexico, one of the most prestigious universities in Mexico. She has always had a great interest in the field of medical research, and during the first year of medicine school she participated in the development of clinical research protocols with main topics such as “child malnutrition,” “gynecological infections”, and “genetic aspects of alcoholism”. During the fourth year of medicine, she participated in a research protocol entitled "genetic aspects of Alzheimer’s disease" in the Brain Bank which is part of the research and advanced studies center, which is a Mexican public institution dedicated to the development of science and technology, by learning brain tissue staining techniques with observation of samples through a confocal microscope and giving talks in health institutions about the genetical aspects of Alzheimer´s disease. In the sixth and last year of her career, as part of her social service, she conducted a one-year research stay at the General Hospital of Mexico, where she was in contact with patients with tuberculosis and she participated in the development of research protocols about Mycobacterium bovis in malnourished patients. Later, that same year, she moved to the National Institute of Respiratory Diseases where she learned electrophoresis, western blot, protein quantification and ultracentrifugation techniques as part of a study protocol entitled “Exosomal miRNAs found in bronchoalveolar lavage of patients with idiopathic pulmonary fibrosis” finding in that research line the inspiration for the realization of this review article. She maintains the desire to continue participating in medical research protocols in the field of ophthalmology since next year 2023 she will begin the residency in ophthalmology in Mexico City.