Alina KostenkoRUDN University, Russian Federation
Title: Characteristics of the gut microbiota in patients with autoimmune thyroiditis at a young age
Relevance of the topic: The prevalence of autoimmune diseases (AIDs) of the thyroid gland (TG) is estimated at about 5% in the world. It is known that microbial imbalance is observed in patients with thyroid AIDs. The features of gut microbiota (GM) disorders in patients with autoimmune thyroiditis (AIT) remain not fully understood, which was the purpose of this study.
Objectives: To analyze the species diversity of gut microbiota in patients with AIT.
Materials and methods. The study involved 10 women with AIT receiving replacement therapy with levothyroxine. Samples of fecal microbiota of patients were studied by using the gas chromatography-mass-spectrometry method.
Results: The average number of representatives of normal GM in 10 samples were Bifidobacterium spp 31 508,4?105 cells/gram (85 828 – 52 182; standard deviation (SD) 13 177,07), Lactobacillus spp 24 439,4 ?105 cells/gram (5 195 – 5 6463; SD 14 739,52), Eubacterium spp 71 714,5 ?105 cells/gram (21 134 – 154 558; SD 39 398,53), Peptostreptococcus anaerobius 27 012,9 ?105 cells/gram (11 993 – 52 964; SD 13 971,95). All analyses showed a decrease in Enterobacteriaceae spp. below 105 cells/gram and high levels of pathogens ?lostridium perfingens 146 209,8?105 cells/gram (23 583 – 805 475; standard deviation (SD) 242 165,6) and Clostridium spp (?. tetani group) 29 001,1?105 cells/gram (2 764 – 217 643; standard deciation (SD) 67 043,5). Also, Streptococcus mutans, Propionibacterium jensenii, Actinomyces viscosus, Prevotella spp, Streptomyces spp dominated in composition of GM. The most common microorganisms were Pseudomonas aeruginosa, Alcaligenes spp./Klebsiella spp, Moraxella spp./Acinetobacter spp.
Conclusion: This work demonstrates the preliminary results of an ongoing study of GM in patients with AIT. According to the data obtained, patients with AIT suffer from intestinal dysbacteriosis. Further study of the composition of GM will allow identifying groups of microorganisms associated with AIT and developing methods for correcting GM disorders in order to improve the effectiveness of AIT treatment.
Alina Kostenko is practicing doctor, endogrinologist, postgraduate student People’s Friendship University of Russia. Areal of scientific interests is autoimmune diseases of the thyroid gland and diabetes mellitus.